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Application Notes for Enantioselective Gas Chromatography

Application notes

• Linalool / Linalylacetate on 6T-23Ac-beta-CD ("TA")
  Simultaneous resolution of the enantiomers of linalool and linalyl acetate. This application is suited to separate and resolve the title compounds as commonly required in essential oil analysis. A wide range of temperature programs may be used to optimise the method with regards to individual matrix requirements. Baseline separation can be achieved easily and quantification is possible. All columns of this type ("TA") supplied by us are individually tested to achieve this resolution.
• Ambrox on 6T-23Me-beta-CD ("TM")
  Enantiomeric resolution of ambrox with a high alpha value. Higher temperatures will give baseline separations in significantly shorter time.
• Diterpene Sclareol on 6T-23Me-beta-CD ("TM")
  This application is an example for a diterpene resolution. Due to the high separation efficiency at elevated temperatures this stationary phase may be employed for the analysis of compounds with higher molecular weight and lower volatility. Many polychlorinated biphenyls, halogenated pesticides, paracyclophanes and similar aromatic compounds may be separated and resolved.
• Spiroalkanes on 6-Me-2,3-Pe-gamma-CD ("G")
  Column "G" is particularly suited to separate medium-polar compounds like ethers, ketones,lactones, alkohols, esters and related substance classes like oxygenated monoterpenes and sesquiterpenes. The majority of monoterpene hydrocarbons can be separated. Even at fairly low temperatures (40 °C) excellent enantioseparations of high-volatile compounds can be achieved.
• 4-Methyl-3-heptanone on 6-Me-2,3-Pe-gamma-CD ("G")
  A typical example of an excellent separation factor for a high-volatile, medium polar oxygenated compound. Down to fairly low temperatures (40 °C) excellent enantioseparations of high-volatile compounds can be achieved.
• Menthol and Menthone isomers on 6-Me-2,3-Pe-gamma-CD ("G")
  The important isomers and enantiomers of menthone, isomenthone, neomenthol, neoisomenthol and menthol can be separated in a single run. This is a demonstration of the separation capabilities regarding oxygenated monoterpenes and related classes as lactones, ethers and ketones.
• Isotopic Isomers on 3-Bc-2,6-Pe-gamma-CD ("E")
  Column type "E" is particularly useful for all medium-polar compounds in the whole volatility range, from elution temperatures of 60 °C up to 180 °C. This application shows the simultaneous enantioseparation of two isotopic isomers (hydrogen/deuterium) in all 4 species. Column "E" is known for its wide variety of very special separation capabilities.

A plethora of further applications...

If you are interested in other applications, please drop us an email! We will be glad to assist you in selecting a column suitable for your requirements. We have a huge collection of further applications and will give advice free of charge.

However, each day new separation needs arise and in many cases method development by trial-and-error is necessary. We can recommend specific columns that most likely achieve your enantiomeric resolutions, but we can not guarantee so for compounds we have not studied in our own laboratory.